Endocrine Abstracts

Introduction: The aim of this study was to assess the efficacy of peptide receptor radionuclide therapy (PRRT) with the use of 90Y-DOTATATE and the survival rate of patients with disseminated or non-operable neuroendocrine tumors (NETs).Methods: In the time period from June 2006 to October 2012, 70 patients were treated with PRRT in our department. The 90Y-DOTATATE therapeutic activity was calculated per total body surface area up t...

Objective: The aim of this study was to quantitatively estimate SSTR2 in clinically non-functioning pituitary adenomas (CNFAs) with use of RNA in-situ hybridization (ISH) and quantitative real-time RT-PCR and correlate the results of both methods.Methods: A standard histological and immunohistochemical examination was performed on the resected pituitary tumour. Afterwards in-situ hybridization for somatostatine 2 receptor (SSTR2) RNA wa...

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)Craniopharyngioma (CP), Rathke’s cyst (RC) and xanthogranuloma (XG) are closely related rare sellar masses, which share common embryogenic origin. Treatment strategies in children lack consensus, especially in terms of surgical and radiooncological treatment options.Objective: To study clinical manifestations and treatment-related outco-me in RC, XG, and CP patients.</...

Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL-12 is a proinflammatory cytokine with proatherogenic properties. IL-12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL-12. The aim of the present study was to estimate serum IL-12 and p40 subunit in ...

Polycystic ovary syndrome (PCOS) is heterogeneous disorder leading to infertility. The introduction of Rotterdam criteria creates different PCOS phenotypes, i.e. hyperandrogenic anovulatory with (A) and without (B) polycystic ovaries (PCO) morphology in ultrasonography (usg), hyperandrogenic ovulatory with PCO morphology in usg (C), non-hyperandrogenic anovulatory with PCO morphology in usg (D). In PCOS insulin resistance might be involved in the development of endocrine and m...

Fibroblast growth factor 21 (FGF21) might increase glucose uptake in adipocytes and reduce plasma glucose and triglycerides in animal models of diabetes. The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation. We examined 76 subjects with normal glucose tolerance, 36 lean (BMI <25 kg/m2) and 39 overweight or obese...

The melanocortin system is significant for energy homeostasis and receptors have distinct tissue specific expression. The melanocortin 2-receptor (Mc2r) transmits ACTH dependent signalling in the adrenal cortex. Increased expression in adipocytes during differentiation indicates relevance for lipid homeostasis. Mc2r activation in adipocytes results in increased lipolysis, however, implication compared to norepinephrine (NE) stimulated lipolysis is unknown. To further define fu...

Introduction: In accordance with a rising number of pregnant women with thyroid gland dysfunctions, The Thyroid Gland’s Disorders Outpatient Clinic for Pregnant Women has started its activity in our Endocrinology Department in January 2008. Patients with or without thyroid gland dysfunction in history have been under medical care.During pregnancy thyroid gland is prone to the number of physiological changes, which cause difficulties in the interpret...

The incidence of gastric neuroendocrine tumors (GNT) is increasing, what can be explained by the increased detection caused by the common use of the endoscopy and the pervasive use of acid suppressive therapy leading to enterochromatofine like cells proliferation. There are numerous new diagnostic/therapeutic GNT methods in use like: EUS, SRS, somatostatin therapy and 90Y/177Lu-DOTA-TATE radiotherapy.Materials and methods: In 1998–2008 37 patients w...

Polycystic ovary syndrome (PCOS) is a main cause of women infertility. There are data suggesting an increased risk for cardiovascular disease in PCOS. Insulin resistance might play a role in the pathogenesis of PCOS and its metabolic complications. The aim of the study was to asses the prevalence of The National Cholesterol Education Program (NCEP)-defined metabolic syndrome (MS) in women with PCOS in relation to insulin resistance and endothelial dysfunction – soluble E-...